Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1.

Green, Brian D

Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1. [electronic resource] - Biological chemistry Dec 2003 - 1543-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1431-6730

10.1515/BC.2003.171 doi


Adenosine Deaminase--metabolism
Amino Acid Substitution
Animals
Binding, Competitive
Blood Glucose--drug effects
Cell Line, Tumor
Cricetinae
Cyclic AMP--metabolism
Diabetes Mellitus, Type 2--drug therapy
Dipeptidyl Peptidase 4
Fibroblasts--metabolism
Glucagon--genetics
Glucagon-Like Peptide 1
Glucagon-Like Peptide-1 Receptor
Glucose--pharmacology
Glutamine--chemistry
Glycoproteins--metabolism
Humans
Hypoglycemic Agents--metabolism
Insulin--blood
Insulin Secretion
Islets of Langerhans--drug effects
Mice
Mice, Obese
Peptide Fragments--genetics
Phenylalanine--chemistry
Proline--chemistry
Protein Precursors--genetics
Rats
Receptors, Glucagon--metabolism
Spectrometry, Mass, Electrospray Ionization
Transformation, Genetic
Tyrosine--chemistry