Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide. [electronic resource]
Producer: 20040420Description: 4761-8 p. digitalISSN:- 0968-0896
- Animals
- Benzamides -- chemical synthesis
- Brain -- metabolism
- Cell Membrane -- metabolism
- Crystallography, X-Ray
- Guinea Pigs
- Ligands
- Molecular Conformation
- Molecular Structure
- Piperazines -- chemical synthesis
- Radioligand Assay
- Rats
- Receptors, Opioid, delta -- agonists
- Receptors, Opioid, mu -- agonists
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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