Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide.
Kim, In Jong
Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide. [electronic resource] - Bioorganic & medicinal chemistry Nov 2003 - 4761-8 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0968-0896
10.1016/s0968-0896(03)00496-6 doi
Animals
Benzamides--chemical synthesis
Brain--metabolism
Cell Membrane--metabolism
Crystallography, X-Ray
Guinea Pigs
Ligands
Molecular Conformation
Molecular Structure
Piperazines--chemical synthesis
Radioligand Assay
Rats
Receptors, Opioid, delta--agonists
Receptors, Opioid, mu--agonists
Stereoisomerism
Structure-Activity Relationship
Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide. [electronic resource] - Bioorganic & medicinal chemistry Nov 2003 - 4761-8 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0968-0896
10.1016/s0968-0896(03)00496-6 doi
Animals
Benzamides--chemical synthesis
Brain--metabolism
Cell Membrane--metabolism
Crystallography, X-Ray
Guinea Pigs
Ligands
Molecular Conformation
Molecular Structure
Piperazines--chemical synthesis
Radioligand Assay
Rats
Receptors, Opioid, delta--agonists
Receptors, Opioid, mu--agonists
Stereoisomerism
Structure-Activity Relationship