Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. [electronic resource]
Producer: 20040115Description: 50624-34 p. digitalISSN:- 0021-9258
- Apoptosis
- Blotting, Western
- Caspase 8
- Caspase 9
- Caspases -- metabolism
- Cell Death
- Cell Line
- Cell Line, Tumor
- Cytochromes c -- metabolism
- Cytosol -- metabolism
- Down-Regulation
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Flow Cytometry
- Humans
- Jurkat Cells
- Membrane Potentials
- Microscopy, Fluorescence
- Mitochondria -- metabolism
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases -- metabolism
- Models, Biological
- Phosphorylation
- Plasmids -- metabolism
- Protein Transport
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2
- Sphingosine -- analogs & derivatives
- Tetradecanoylphorbol Acetate -- pharmacology
- Time Factors
- bcl-2-Associated X Protein
- p38 Mitogen-Activated Protein Kinases
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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