Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.

Park, Moon-Taek

Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. [electronic resource] - The Journal of biological chemistry Dec 2003 - 50624-34 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M309011200 doi


Apoptosis
Blotting, Western
Caspase 8
Caspase 9
Caspases--metabolism
Cell Death
Cell Line
Cell Line, Tumor
Cytochromes c--metabolism
Cytosol--metabolism
Down-Regulation
Enzyme Activation
Enzyme Inhibitors--pharmacology
Flow Cytometry
Humans
Jurkat Cells
Membrane Potentials
Microscopy, Fluorescence
Mitochondria--metabolism
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Models, Biological
Phosphorylation
Plasmids--metabolism
Protein Transport
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2
Sphingosine--analogs & derivatives
Tetradecanoylphorbol Acetate--pharmacology
Time Factors
bcl-2-Associated X Protein
p38 Mitogen-Activated Protein Kinases