M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. [electronic resource]
Producer: 20040607Description: 1165-77 p. digitalISSN:- 1350-9047
- Acid Phosphatase -- metabolism
- Actins -- metabolism
- Adaptor Proteins, Signal Transducing
- Alendronate -- pharmacology
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Bone Marrow Cells -- cytology
- Bone Resorption -- metabolism
- Carrier Proteins -- metabolism
- Caspase 3
- Caspase 9
- Caspases -- metabolism
- Cell Cycle Proteins
- Cell Survival -- drug effects
- Collagen -- metabolism
- Collagen Type I
- Cytokines -- pharmacology
- Diterpenes -- pharmacology
- Enzyme Inhibitors -- pharmacology
- Eukaryotic Initiation Factors
- Immunohistochemistry
- Interleukin-1 -- pharmacology
- Isoenzymes -- metabolism
- Macrophage Colony-Stimulating Factor -- pharmacology
- Membrane Glycoproteins -- pharmacology
- Mice
- Models, Biological
- NF-kappa B -- analysis
- Osteoclasts -- cytology
- Peptides -- metabolism
- Phosphoproteins -- metabolism
- Protein Kinases -- physiology
- Protein Serine-Threonine Kinases -- metabolism
- Protein Synthesis Inhibitors -- pharmacology
- Proto-Oncogene Proteins -- analysis
- Proto-Oncogene Proteins c-akt
- RANK Ligand
- Receptor Activator of Nuclear Factor-kappa B
- Ribosomal Protein S6 -- metabolism
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Serine-Threonine Kinase 3
- Signal Transduction -- physiology
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases
- Tartrate-Resistant Acid Phosphatase
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article
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