M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.

Glantschnig, H

M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. [electronic resource] - Cell death and differentiation Oct 2003 - 1165-77 p. digital

Publication Type: Journal Article

1350-9047

10.1038/sj.cdd.4401285 doi


Acid Phosphatase--metabolism
Actins--metabolism
Adaptor Proteins, Signal Transducing
Alendronate--pharmacology
Alkyl and Aryl Transferases--antagonists & inhibitors
Animals
Apoptosis--drug effects
Blotting, Western
Bone Marrow Cells--cytology
Bone Resorption--metabolism
Carrier Proteins--metabolism
Caspase 3
Caspase 9
Caspases--metabolism
Cell Cycle Proteins
Cell Survival--drug effects
Collagen--metabolism
Collagen Type I
Cytokines--pharmacology
Diterpenes--pharmacology
Enzyme Inhibitors--pharmacology
Eukaryotic Initiation Factors
Immunohistochemistry
Interleukin-1--pharmacology
Isoenzymes--metabolism
Macrophage Colony-Stimulating Factor--pharmacology
Membrane Glycoproteins--pharmacology
Mice
Models, Biological
NF-kappa B--analysis
Osteoclasts--cytology
Peptides--metabolism
Phosphoproteins--metabolism
Protein Kinases--physiology
Protein Serine-Threonine Kinases--metabolism
Protein Synthesis Inhibitors--pharmacology
Proto-Oncogene Proteins--analysis
Proto-Oncogene Proteins c-akt
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Ribosomal Protein S6--metabolism
Ribosomal Protein S6 Kinases, 70-kDa--metabolism
Serine-Threonine Kinase 3
Signal Transduction--physiology
Sirolimus--pharmacology
TOR Serine-Threonine Kinases
Tartrate-Resistant Acid Phosphatase
Tumor Necrosis Factor-alpha--pharmacology