Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. [electronic resource]
Producer: 20040112Description: 47370-5 p. digitalISSN:- 0021-9258
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor -- metabolism
- Animals
- Aspartic Acid Endopeptidases
- Binding, Competitive
- Blotting, Western
- Cell Line
- Cell Line, Tumor
- Down-Regulation
- Endopeptidases -- metabolism
- Enzyme-Linked Immunosorbent Assay
- Feedback, Physiological
- Humans
- Luciferases -- metabolism
- Membrane Proteins -- biosynthesis
- Mice
- Plasmids -- metabolism
- Presenilin-1
- Protein Binding
- Protein Structure, Tertiary
- Receptor, Notch1
- Receptors, Cell Surface -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Transcription Factors
- Transfection
- beta-Galactosidase -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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