Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó, Alberto

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. [electronic resource] - The Journal of biological chemistry Nov 2003 - 47370-5 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M308480200 doi


Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor--metabolism
Animals
Aspartic Acid Endopeptidases
Binding, Competitive
Blotting, Western
Cell Line
Cell Line, Tumor
Down-Regulation
Endopeptidases--metabolism
Enzyme-Linked Immunosorbent Assay
Feedback, Physiological
Humans
Luciferases--metabolism
Membrane Proteins--biosynthesis
Mice
Plasmids--metabolism
Presenilin-1
Protein Binding
Protein Structure, Tertiary
Receptor, Notch1
Receptors, Cell Surface--genetics
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Transcription Factors
Transfection
beta-Galactosidase--metabolism