Discovery and preclinical characterization of (+)-3-[4-(1- piperidinoethoxy)phenyl]spiro[indene- 1,1'-indane]-5,5'-diol hydrochloride: a promising nonsteroidal estrogen receptor agonist for hot flush. [electronic resource]
Producer: 20031110Description: 3961-4 p. digitalISSN:- 0022-2623
- Animals
- Bone Density -- drug effects
- Breast Neoplasms -- metabolism
- Cholesterol -- blood
- Drug Evaluation, Preclinical
- Estradiol -- analogs & derivatives
- Female
- Hot Flashes -- drug therapy
- Indans -- chemistry
- Male
- Morphine Dependence -- metabolism
- Naloxone -- pharmacology
- Piperidines -- chemistry
- Rats
- Rats, Sprague-Dawley
- Receptors, Estrogen -- agonists
- Selective Estrogen Receptor Modulators -- chemistry
- Skin Temperature -- drug effects
- Spiro Compounds -- chemistry
- Stereoisomerism
- Tumor Cells, Cultured
- Uterus -- drug effects
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Publication Type: Comparative Study; Journal Article
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