Discovery and preclinical characterization of (+)-3-[4-(1- piperidinoethoxy)phenyl]spiro[indene- 1,1'-indane]-5,5'-diol hydrochloride: a promising nonsteroidal estrogen receptor agonist for hot flush.

Watanabe, Nobuhide

Discovery and preclinical characterization of (+)-3-[4-(1- piperidinoethoxy)phenyl]spiro[indene- 1,1'-indane]-5,5'-diol hydrochloride: a promising nonsteroidal estrogen receptor agonist for hot flush. [electronic resource] - Journal of medicinal chemistry Sep 2003 - 3961-4 p. digital

Publication Type: Comparative Study; Journal Article

0022-2623

10.1021/jm034134+ doi


Animals
Bone Density--drug effects
Breast Neoplasms--metabolism
Cholesterol--blood
Drug Evaluation, Preclinical
Estradiol--analogs & derivatives
Female
Hot Flashes--drug therapy
Indans--chemistry
Male
Morphine Dependence--metabolism
Naloxone--pharmacology
Piperidines--chemistry
Rats
Rats, Sprague-Dawley
Receptors, Estrogen--agonists
Selective Estrogen Receptor Modulators--chemistry
Skin Temperature--drug effects
Spiro Compounds--chemistry
Stereoisomerism
Tumor Cells, Cultured
Uterus--drug effects