Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability. [electronic resource]
Producer: 20031007Description: 10169-73 p. digitalISSN:- 0006-2960
- Amino Acid Substitution
- Antithrombins -- chemistry
- Drug Stability
- Heparin -- analogs & derivatives
- Hot Temperature
- Humans
- Kinetics
- Models, Molecular
- Mutagenesis, Site-Directed
- Osmolar Concentration
- Protein Denaturation
- Protein Structure, Secondary
- Recombinant Proteins -- chemistry
- Structure-Activity Relationship
- alpha 1-Antitrypsin -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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