Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability. (Record no. 12709299)

MARC details
000 -LEADER
fixed length control field 01619 a2200457 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250514075707.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 200310s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0006-2960
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1021/bi0349322
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Quinsey, Noelene S
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 20031007
245 00 - TITLE STATEMENT
Title Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability.
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Biochemistry
Date of publication, distribution, etc. Sep 2003
300 ## - PHYSICAL DESCRIPTION
Extent 10169-73 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Amino Acid Substitution
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Antithrombins
General subdivision chemistry
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Drug Stability
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Heparin
General subdivision analogs & derivatives
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hot Temperature
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Kinetics
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Models, Molecular
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mutagenesis, Site-Directed
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Osmolar Concentration
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Denaturation
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Structure, Secondary
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Recombinant Proteins
General subdivision chemistry
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Structure-Activity Relationship
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element alpha 1-Antitrypsin
General subdivision chemistry
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Fitton, Hazel L
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Coughlin, Paul
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Whisstock, James C
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Dafforn, Timothy R
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Carrell, Robin W
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Bottomley, Stephen P
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Pike, Robert N
773 0# - HOST ITEM ENTRY
Title Biochemistry
Related parts vol. 42
-- no. 34
-- p. 10169-73
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1021/bi0349322">https://doi.org/10.1021/bi0349322</a>
Public note Available from publisher's website

No items available.