Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication. [electronic resource]
Producer: 20031106Description: 39092-103 p. digitalISSN:- 0021-9258
- Animals
- Antiviral Agents -- pharmacology
- Automation
- Carbamates -- chemistry
- Cells, Cultured
- Chromatography, Gas
- Dose-Response Relationship, Drug
- Fluorescence Resonance Energy Transfer
- Gene Products, tat -- chemistry
- HIV-1 -- chemistry
- HeLa Cells
- Humans
- Ligands
- Mice
- Models, Biological
- Models, Chemical
- Models, Statistical
- Nucleic Acid Conformation
- Oligopeptides -- chemistry
- Peptide Library
- Protein Binding
- RNA -- chemistry
- RNA-Directed DNA Polymerase -- metabolism
- Structure-Activity Relationship
- Transcriptional Activation
- tat Gene Products, Human Immunodeficiency Virus
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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