The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate. [electronic resource]
Producer: 20031017Description: 2229-35 p. digitalISSN:- 0006-4971
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- metabolism
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzamides
- Cell Division -- drug effects
- Diphosphonates -- pharmacology
- Drug Synergism
- HL-60 Cells
- Hematopoietic Stem Cells -- cytology
- Humans
- Imatinib Mesylate
- Imidazoles -- pharmacology
- K562 Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Monomeric GTP-Binding Proteins -- metabolism
- Pamidronate
- Piperazines -- pharmacology
- Protein Prenylation
- Pyrimidines -- pharmacology
- Zoledronic Acid
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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