The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate.
Kuroda, Junya
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate. [electronic resource] - Blood Sep 2003 - 2229-35 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-4971
10.1182/blood-2003-01-0305 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Benzamides
Cell Division--drug effects
Diphosphonates--pharmacology
Drug Synergism
HL-60 Cells
Hematopoietic Stem Cells--cytology
Humans
Imatinib Mesylate
Imidazoles--pharmacology
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Mice
Mice, Inbred NOD
Mice, SCID
Monomeric GTP-Binding Proteins--metabolism
Pamidronate
Piperazines--pharmacology
Protein Prenylation
Pyrimidines--pharmacology
Zoledronic Acid
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate. [electronic resource] - Blood Sep 2003 - 2229-35 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-4971
10.1182/blood-2003-01-0305 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Benzamides
Cell Division--drug effects
Diphosphonates--pharmacology
Drug Synergism
HL-60 Cells
Hematopoietic Stem Cells--cytology
Humans
Imatinib Mesylate
Imidazoles--pharmacology
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Mice
Mice, Inbred NOD
Mice, SCID
Monomeric GTP-Binding Proteins--metabolism
Pamidronate
Piperazines--pharmacology
Protein Prenylation
Pyrimidines--pharmacology
Zoledronic Acid