Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis. [electronic resource]
Producer: 20030604Description: 919-24 p. digitalISSN:- 0887-6924
- Adult
- Bone Marrow -- metabolism
- Cell Cycle Proteins -- genetics
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16 -- genetics
- DNA Methylation
- DNA Primers -- chemistry
- DNA, Neoplasm -- genetics
- Dinucleoside Phosphates -- genetics
- Enzyme Inhibitors -- metabolism
- Female
- Follow-Up Studies
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Genes, Tumor Suppressor
- Humans
- Immunoenzyme Techniques
- Leukemia, Promyelocytic, Acute -- genetics
- Male
- Neoplasm Recurrence, Local -- genetics
- Polymerase Chain Reaction
- Prognosis
- Promoter Regions, Genetic -- genetics
- RNA, Messenger -- genetics
- RNA, Neoplasm -- genetics
- Sulfites -- metabolism
- Survival Rate
- Syndrome
- Treatment Outcome
- Tumor Suppressor Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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