Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis.

Teofili, L

Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis. [electronic resource] - Leukemia May 2003 - 919-24 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0887-6924

10.1038/sj.leu.2402907 doi


Adult
Bone Marrow--metabolism
Cell Cycle Proteins--genetics
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16--genetics
DNA Methylation
DNA Primers--chemistry
DNA, Neoplasm--genetics
Dinucleoside Phosphates--genetics
Enzyme Inhibitors--metabolism
Female
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Gene Silencing
Genes, Tumor Suppressor
Humans
Immunoenzyme Techniques
Leukemia, Promyelocytic, Acute--genetics
Male
Neoplasm Recurrence, Local--genetics
Polymerase Chain Reaction
Prognosis
Promoter Regions, Genetic--genetics
RNA, Messenger--genetics
RNA, Neoplasm--genetics
Sulfites--metabolism
Survival Rate
Syndrome
Treatment Outcome
Tumor Suppressor Proteins