Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand. [electronic resource]
Producer: 20030513Description: 2403-8 p. digitalISSN:- 0027-8424
- Animals
- CHO Cells
- Cell Line
- Cricetinae
- DNA, Complementary -- metabolism
- Dose-Response Relationship, Drug
- Flow Cytometry
- Genetic Linkage
- Glycosylation
- Humans
- Integrin alphaVbeta3 -- chemistry
- Integrins -- chemistry
- Ligands
- Models, Molecular
- Mutation
- Phenotype
- Plasmids -- metabolism
- Polysaccharides -- chemistry
- Protein Binding
- Protein Conformation
- Protein Structure, Tertiary
- Transfection
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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