The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195. [electronic resource]
Producer: 20030512Description: 961-7 p. digitalISSN:- 1535-7163
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Benzopyrans -- pharmacology
- Blotting, Western
- Caspase Inhibitors
- Caspases -- metabolism
- Cell Survival
- Cell-Free System
- Cells, Cultured
- Coloring Agents -- pharmacology
- Cytochrome c Group -- metabolism
- Cytosol -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- HL-60 Cells
- Humans
- In Situ Nick-End Labeling
- Isoquinolines -- pharmacology
- Mice
- Microscopy, Fluorescence
- Mitochondria -- drug effects
- Nitriles -- pharmacology
- Protein Transport
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Subcellular Fractions
- Tetrazolium Salts -- pharmacology
- Thiazoles -- pharmacology
- Time Factors
- bcl-2-Associated X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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