The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195.

Chen, Jun

The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195. [electronic resource] - Molecular cancer therapeutics Oct 2002 - 961-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1535-7163


Animals
Antineoplastic Agents--pharmacology
Apoptosis
Benzopyrans--pharmacology
Blotting, Western
Caspase Inhibitors
Caspases--metabolism
Cell Survival
Cell-Free System
Cells, Cultured
Coloring Agents--pharmacology
Cytochrome c Group--metabolism
Cytosol--metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacology
HL-60 Cells
Humans
In Situ Nick-End Labeling
Isoquinolines--pharmacology
Mice
Microscopy, Fluorescence
Mitochondria--drug effects
Nitriles--pharmacology
Protein Transport
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
Subcellular Fractions
Tetrazolium Salts--pharmacology
Thiazoles--pharmacology
Time Factors
bcl-2-Associated X Protein