Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. [electronic resource]
Producer: 20030522Description: 14487-97 p. digitalISSN:- 0021-9258
- Animals
- Blotting, Western
- Cell Line
- Cell Movement
- Cell Nucleus -- metabolism
- Cell Survival
- Curcumin -- pharmacology
- Cytoplasm -- metabolism
- Dose-Response Relationship, Drug
- Down-Regulation
- Enzyme Activation
- Genes, Reporter
- I-kappa B Proteins -- metabolism
- Luciferases -- metabolism
- Matrix Metalloproteinase 2 -- metabolism
- Mice
- Mice, Nude
- Microscopy, Fluorescence
- Models, Biological
- NF-KappaB Inhibitor alpha
- NF-kappa B -- chemistry
- Neoplasm Transplantation
- Osteopontin
- Phosphorylation
- Protein Binding
- Protein Precursors -- chemistry
- Sialoglycoproteins -- physiology
- Signal Transduction
- Transcription Factor RelA
- Transcriptional Activation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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