Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways.

Philip, Subha

Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. [electronic resource] - The Journal of biological chemistry Apr 2003 - 14487-97 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M207309200 doi


Animals
Blotting, Western
Cell Line
Cell Movement
Cell Nucleus--metabolism
Cell Survival
Curcumin--pharmacology
Cytoplasm--metabolism
Dose-Response Relationship, Drug
Down-Regulation
Enzyme Activation
Genes, Reporter
I-kappa B Proteins--metabolism
Luciferases--metabolism
Matrix Metalloproteinase 2--metabolism
Mice
Mice, Nude
Microscopy, Fluorescence
Models, Biological
NF-KappaB Inhibitor alpha
NF-kappa B--chemistry
Neoplasm Transplantation
Osteopontin
Phosphorylation
Protein Binding
Protein Precursors--chemistry
Sialoglycoproteins--physiology
Signal Transduction
Transcription Factor RelA
Transcriptional Activation