Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.
Blat, Yuval
Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. [electronic resource] - Biochemical and biophysical research communications Dec 2002 - 569-73 p. digital
Publication Type: Journal Article
0006-291X
10.1016/s0006-291x(02)02705-5 doi
Acetylcysteine--analogs & derivatives
Amyloid Precursor Protein Secretases
Animals
Aspartic Acid Endopeptidases
Cell Line
Cell-Free System
Cells, Cultured
Cysteine Proteinase Inhibitors--metabolism
Endopeptidases--metabolism
Fibroblasts--cytology
Humans
Membrane Proteins--genetics
Mice
Mice, Knockout
Molecular Structure
Mutation
Protein Structure, Tertiary
Receptor, Notch1
Receptors, Cell Surface
Transcription Factors
Valine--metabolism
Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. [electronic resource] - Biochemical and biophysical research communications Dec 2002 - 569-73 p. digital
Publication Type: Journal Article
0006-291X
10.1016/s0006-291x(02)02705-5 doi
Acetylcysteine--analogs & derivatives
Amyloid Precursor Protein Secretases
Animals
Aspartic Acid Endopeptidases
Cell Line
Cell-Free System
Cells, Cultured
Cysteine Proteinase Inhibitors--metabolism
Endopeptidases--metabolism
Fibroblasts--cytology
Humans
Membrane Proteins--genetics
Mice
Mice, Knockout
Molecular Structure
Mutation
Protein Structure, Tertiary
Receptor, Notch1
Receptors, Cell Surface
Transcription Factors
Valine--metabolism