Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. [electronic resource]
Producer: 20030115Description: 15170-5 p. digitalISSN:- 0027-8424
- Amino Acid Substitution
- Animals
- Anti-Anxiety Agents -- pharmacology
- Cell Line
- Diazepam -- pharmacology
- Epilepsy -- genetics
- Flunitrazepam -- pharmacology
- Humans
- Kinetics
- Membrane Potentials -- drug effects
- Mutagenesis, Site-Directed
- Neurons -- physiology
- Oocytes -- drug effects
- Patch-Clamp Techniques
- Protein Subunits -- genetics
- Pyridines -- pharmacology
- Receptors, GABA-A -- genetics
- Recombinant Proteins -- metabolism
- Synapses -- physiology
- Synaptic Transmission
- Transfection
- Xenopus
- Zolpidem
- gamma-Aminobutyric Acid -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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