Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.

Bowser, David N

Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Nov 2002 - 15170-5 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0027-8424

10.1073/pnas.212320199 doi


Amino Acid Substitution
Animals
Anti-Anxiety Agents--pharmacology
Cell Line
Diazepam--pharmacology
Epilepsy--genetics
Flunitrazepam--pharmacology
Humans
Kinetics
Membrane Potentials--drug effects
Mutagenesis, Site-Directed
Neurons--physiology
Oocytes--drug effects
Patch-Clamp Techniques
Protein Subunits--genetics
Pyridines--pharmacology
Receptors, GABA-A--genetics
Recombinant Proteins--metabolism
Synapses--physiology
Synaptic Transmission
Transfection
Xenopus
Zolpidem
gamma-Aminobutyric Acid--pharmacology