A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur. [electronic resource]
Producer: 20021107Description: 299-306 p. digitalISSN:- 0960-314X
- Administration, Oral
- Antimetabolites, Antineoplastic -- administration & dosage
- Area Under Curve
- Aryl Hydrocarbon Hydroxylases -- genetics
- Coumarins -- metabolism
- Cytochrome P-450 CYP2A6
- DNA Primers -- chemistry
- DNA, Neoplasm -- blood
- Drug Combinations
- Escherichia coli
- Genotype
- Humans
- Kinetics
- Middle Aged
- Mixed Function Oxygenases -- genetics
- Mutagenesis, Site-Directed
- Oxonic Acid -- administration & dosage
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Pyridines -- administration & dosage
- Recombinant Proteins -- isolation & purification
- Stomach Neoplasms -- enzymology
- Tegafur -- administration & dosage
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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