Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. [electronic resource]
Producer: 20020430Description: 1028-33 p. digitalISSN:- 0007-0920
- Aged
- Alleles
- Antimetabolites, Antineoplastic -- adverse effects
- Chromatography, High Pressure Liquid
- Colorectal Neoplasms -- drug therapy
- DNA, Neoplasm -- genetics
- Dihydrouracil Dehydrogenase (NADP)
- Female
- Fluorouracil -- adverse effects
- Humans
- Leucovorin -- administration & dosage
- Male
- Middle Aged
- Oxidoreductases -- genetics
- Point Mutation
- Polymerase Chain Reaction
- Sequence Analysis, DNA
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Publication Type: Case Reports; Journal Article
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