Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.
Maring, J G
Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. [electronic resource] - British journal of cancer Apr 2002 - 1028-33 p. digital
Publication Type: Case Reports; Journal Article
0007-0920
10.1038/sj.bjc.6600208 doi
Aged
Alleles
Antimetabolites, Antineoplastic--adverse effects
Chromatography, High Pressure Liquid
Colorectal Neoplasms--drug therapy
DNA, Neoplasm--genetics
Dihydrouracil Dehydrogenase (NADP)
Female
Fluorouracil--adverse effects
Humans
Leucovorin--administration & dosage
Male
Middle Aged
Oxidoreductases--genetics
Point Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA
Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. [electronic resource] - British journal of cancer Apr 2002 - 1028-33 p. digital
Publication Type: Case Reports; Journal Article
0007-0920
10.1038/sj.bjc.6600208 doi
Aged
Alleles
Antimetabolites, Antineoplastic--adverse effects
Chromatography, High Pressure Liquid
Colorectal Neoplasms--drug therapy
DNA, Neoplasm--genetics
Dihydrouracil Dehydrogenase (NADP)
Female
Fluorouracil--adverse effects
Humans
Leucovorin--administration & dosage
Male
Middle Aged
Oxidoreductases--genetics
Point Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA