The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. [electronic resource]
Producer: 20020719Description: 22370-6 p. digitalISSN:- 0021-9258
- 3T3 Cells
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Animals
- Base Sequence
- Cell Line
- Cell Lineage
- Cytosine -- metabolism
- Gene Silencing
- Histone Deacetylases -- metabolism
- Histones -- metabolism
- Humans
- Hydroxamic Acids -- pharmacology
- Luciferases -- metabolism
- Methylation
- Mice
- Models, Genetic
- Molecular Sequence Data
- Plasmids -- metabolism
- Promoter Regions, Genetic
- Protein Isoforms
- Protein Structure, Tertiary
- Proteins -- genetics
- RNA, Messenger -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Ribonucleases -- metabolism
- Shc Signaling Adaptor Proteins
- Src Homology 2 Domain-Containing, Transforming Protein 1
- Time Factors
- Transcription, Genetic
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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