MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity. [electronic resource]
Producer: 20020516Description: 3014-23 p. digitalISSN:- 0270-7306
- Animals
- CDC2-CDC28 Kinases
- Cell Cycle -- drug effects
- Cell Cycle Proteins -- metabolism
- Cell Differentiation
- Cell Line
- Cyclin E -- antagonists & inhibitors
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Fatty Acids, Unsaturated -- pharmacology
- Female
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Genes, myc -- genetics
- Granulocytes -- cytology
- Hematopoietic Stem Cells -- metabolism
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nuclear Proteins
- Phosphoproteins -- metabolism
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- RNA, Messenger -- metabolism
- Repressor Proteins -- metabolism
- Retinoblastoma Protein -- metabolism
- Tetrahydronaphthalenes -- pharmacology
- Time Factors
- Tumor Suppressor Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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