MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity.
McArthur, Grant A
MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity. [electronic resource] - Molecular and cellular biology May 2002 - 3014-23 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0270-7306
10.1128/MCB.22.9.3014-3023.2002 doi
Animals
CDC2-CDC28 Kinases
Cell Cycle--drug effects
Cell Cycle Proteins--metabolism
Cell Differentiation
Cell Line
Cyclin E--antagonists & inhibitors
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases--antagonists & inhibitors
Fatty Acids, Unsaturated--pharmacology
Female
Flow Cytometry
Gene Expression Regulation, Neoplastic
Genes, myc--genetics
Granulocytes--cytology
Hematopoietic Stem Cells--metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nuclear Proteins
Phosphoproteins--metabolism
Protein Serine-Threonine Kinases--antagonists & inhibitors
RNA, Messenger--metabolism
Repressor Proteins--metabolism
Retinoblastoma Protein--metabolism
Tetrahydronaphthalenes--pharmacology
Time Factors
Tumor Suppressor Proteins--metabolism
MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity. [electronic resource] - Molecular and cellular biology May 2002 - 3014-23 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0270-7306
10.1128/MCB.22.9.3014-3023.2002 doi
Animals
CDC2-CDC28 Kinases
Cell Cycle--drug effects
Cell Cycle Proteins--metabolism
Cell Differentiation
Cell Line
Cyclin E--antagonists & inhibitors
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases--antagonists & inhibitors
Fatty Acids, Unsaturated--pharmacology
Female
Flow Cytometry
Gene Expression Regulation, Neoplastic
Genes, myc--genetics
Granulocytes--cytology
Hematopoietic Stem Cells--metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nuclear Proteins
Phosphoproteins--metabolism
Protein Serine-Threonine Kinases--antagonists & inhibitors
RNA, Messenger--metabolism
Repressor Proteins--metabolism
Retinoblastoma Protein--metabolism
Tetrahydronaphthalenes--pharmacology
Time Factors
Tumor Suppressor Proteins--metabolism