Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6. [electronic resource]
Producer: 20020425Description: 4568-73 p. digitalISSN:- 0027-8424
- Base Sequence
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 4
- Cloning, Molecular
- Cyclin-Dependent Kinase 6
- Cyclin-Dependent Kinases
- DNA-Binding Proteins -- genetics
- Female
- Gene Rearrangement
- Histone-Lysine N-Methyltransferase
- Humans
- Molecular Sequence Data
- Myeloid-Lymphoid Leukemia Protein
- Nuclear Proteins -- genetics
- Polymerase Chain Reaction -- methods
- Protein Serine-Threonine Kinases -- genetics
- Proto-Oncogenes
- Transcription Factors
- Transcriptional Elongation Factors
- Translocation, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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