Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site. [electronic resource]
Producer: 20020529Description: 450-8 p. digitalISSN:- 0888-8809
- Animals
- Base Sequence
- Binding Sites
- CHO Cells
- Cell Line
- Child, Preschool
- Cricetinae
- Cyclic AMP -- pharmacology
- DNA Mutational Analysis
- DNA-Binding Proteins -- metabolism
- Gene Expression
- Glutamic Acid
- Growth Hormone-Releasing Hormone -- pharmacology
- Heterozygote
- Human Growth Hormone -- deficiency
- Humans
- Luciferases -- genetics
- Lysine
- Male
- Mutation
- Mutation, Missense
- Pituitary Gland -- metabolism
- Promoter Regions, Genetic
- Rats
- Receptors, Neuropeptide -- chemistry
- Receptors, Pituitary Hormone-Regulating Hormone -- chemistry
- Transcription Factor Pit-1
- Transcription Factors -- metabolism
- Transfection
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Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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