Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. [electronic resource]
Producer: 20020429Description: 677-85 p. digitalISSN:- 0014-2980
- Amino Acid Sequence
- Animals
- Apoptosis -- physiology
- Autoimmune Diseases -- genetics
- CASP8 and FADD-Like Apoptosis Regulating Protein
- Carrier Proteins -- biosynthesis
- Caspase 3
- Caspases -- biosynthesis
- Concanavalin A -- pharmacology
- Enzyme Induction -- drug effects
- Enzyme Precursors -- biosynthesis
- Gene Expression Regulation -- drug effects
- Genotype
- Interleukin-2 -- biosynthesis
- Intracellular Signaling Peptides and Proteins
- Lymphocyte Activation -- drug effects
- Mice
- Mice, Inbred MRL lpr
- Mice, Inbred Strains
- Models, Animal
- Molecular Sequence Data
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Receptors, Interleukin-2 -- biosynthesis
- Recombinant Fusion Proteins -- pharmacology
- Sequence Alignment
- Sequence Homology, Amino Acid
- T-Lymphocytes -- drug effects
- bcl-X Protein
- fas Receptor -- immunology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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