Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.

Choi, Youngnim

Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. [electronic resource] - European journal of immunology 03 2002 - 677-85 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0014-2980

10.1002/1521-4141(200203)32:3<677::AID-IMMU677>3.0.CO;2-I doi


Amino Acid Sequence
Animals
Apoptosis--physiology
Autoimmune Diseases--genetics
CASP8 and FADD-Like Apoptosis Regulating Protein
Carrier Proteins--biosynthesis
Caspase 3
Caspases--biosynthesis
Concanavalin A--pharmacology
Enzyme Induction--drug effects
Enzyme Precursors--biosynthesis
Gene Expression Regulation--drug effects
Genotype
Interleukin-2--biosynthesis
Intracellular Signaling Peptides and Proteins
Lymphocyte Activation--drug effects
Mice
Mice, Inbred MRL lpr
Mice, Inbred Strains
Models, Animal
Molecular Sequence Data
Proto-Oncogene Proteins c-bcl-2--biosynthesis
Receptors, Interleukin-2--biosynthesis
Recombinant Fusion Proteins--pharmacology
Sequence Alignment
Sequence Homology, Amino Acid
T-Lymphocytes--drug effects
bcl-X Protein
fas Receptor--immunology