Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. [electronic resource]
Producer: 20020214Description: 337-46 p. digitalISSN:- 0950-9232
- Adenocarcinoma -- metabolism
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins
- CASP8 and FADD-Like Apoptosis Regulating Protein
- Carrier Proteins -- metabolism
- Caspases -- metabolism
- Cell Survival -- drug effects
- Ceramides -- metabolism
- Enzyme Activation -- drug effects
- Glucose -- deficiency
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Membrane Glycoproteins -- toxicity
- Poly(ADP-ribose) Polymerases -- metabolism
- Prostatic Neoplasms -- metabolism
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- Receptors, Tumor Necrosis Factor -- metabolism
- Spectrometry, Mass, Electrospray Ionization
- TNF-Related Apoptosis-Inducing Ligand
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha -- toxicity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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