Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway.

Nam, Seon Young

Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. [electronic resource] - Oncogene Jan 2002 - 337-46 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0950-9232

10.1038/sj.onc.1205068 doi


Adenocarcinoma--metabolism
Apoptosis--drug effects
Apoptosis Regulatory Proteins
CASP8 and FADD-Like Apoptosis Regulating Protein
Carrier Proteins--metabolism
Caspases--metabolism
Cell Survival--drug effects
Ceramides--metabolism
Enzyme Activation--drug effects
Glucose--deficiency
Humans
Intracellular Signaling Peptides and Proteins
Male
Membrane Glycoproteins--toxicity
Poly(ADP-ribose) Polymerases--metabolism
Prostatic Neoplasms--metabolism
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor--metabolism
Spectrometry, Mass, Electrospray Ionization
TNF-Related Apoptosis-Inducing Ligand
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha--toxicity