Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. [electronic resource]
Producer: 20020207Description: 344-59 p. digitalISSN:- 0022-2623
- 3,4-Dihydroxyphenylacetic Acid -- metabolism
- Animals
- Antipsychotic Agents -- chemical synthesis
- Behavior, Animal -- drug effects
- Brain -- metabolism
- Catalepsy -- chemically induced
- Crystallography, X-Ray
- Dopamine -- metabolism
- Dopamine Antagonists -- chemical synthesis
- Homovanillic Acid -- metabolism
- In Vitro Techniques
- Male
- Mice
- Microdialysis
- Models, Molecular
- Molecular Conformation
- Molecular Structure
- Prolactin -- blood
- Pyrroles -- chemical synthesis
- Radioligand Assay
- Rats
- Rats, Inbred F344
- Rats, Wistar
- Receptors, Dopamine D2 -- metabolism
- Stereoisomerism
- Structure-Activity Relationship
- Thiazepines -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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