Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.

Campiani, Giuseppe

Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. [electronic resource] - Journal of medicinal chemistry Jan 2002 - 344-59 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm010982y doi


3,4-Dihydroxyphenylacetic Acid--metabolism
Animals
Antipsychotic Agents--chemical synthesis
Behavior, Animal--drug effects
Brain--metabolism
Catalepsy--chemically induced
Crystallography, X-Ray
Dopamine--metabolism
Dopamine Antagonists--chemical synthesis
Homovanillic Acid--metabolism
In Vitro Techniques
Male
Mice
Microdialysis
Models, Molecular
Molecular Conformation
Molecular Structure
Prolactin--blood
Pyrroles--chemical synthesis
Radioligand Assay
Rats
Rats, Inbred F344
Rats, Wistar
Receptors, Dopamine D2--metabolism
Stereoisomerism
Structure-Activity Relationship
Thiazepines--chemical synthesis