Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. [electronic resource]
Producer: 20020212Description: 113-21 p. digitalISSN:- 0008-5472
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- metabolism
- BRCA1 Protein -- biosynthesis
- Benzo(a)pyrene -- metabolism
- Biotransformation
- Breast Neoplasms -- chemically induced
- Carcinogens -- metabolism
- Down-Regulation
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, BRCA1 -- drug effects
- Humans
- Polychlorinated Dibenzodioxins -- toxicity
- Promoter Regions, Genetic -- drug effects
- RNA, Messenger -- biosynthesis
- Receptors, Aryl Hydrocarbon -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Transcription, Genetic -- drug effects
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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