Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

Jeffy, Brandon D

Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. [electronic resource] - Cancer research Jan 2002 - 113-21 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0008-5472


7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide--metabolism
BRCA1 Protein--biosynthesis
Benzo(a)pyrene--metabolism
Biotransformation
Breast Neoplasms--chemically induced
Carcinogens--metabolism
Down-Regulation
Gene Expression Profiling
Gene Expression Regulation, Neoplastic--drug effects
Genes, BRCA1--drug effects
Humans
Polychlorinated Dibenzodioxins--toxicity
Promoter Regions, Genetic--drug effects
RNA, Messenger--biosynthesis
Receptors, Aryl Hydrocarbon--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Transcription, Genetic--drug effects
Tumor Cells, Cultured
Tumor Suppressor Protein p53--genetics