Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. [electronic resource]
Producer: 20020522Description: 389-94 p. digitalISSN:- 0379-0355
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins -- metabolism
- Calcification, Physiologic -- drug effects
- Calcium -- metabolism
- Cell Line
- Core Binding Factor Alpha 1 Subunit
- Core Binding Factors
- Fatty Acids, Monounsaturated -- pharmacology
- Fluvastatin
- GTPase-Activating Proteins -- antagonists & inhibitors
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Immunohistochemistry
- Indoles -- pharmacology
- Lovastatin -- analogs & derivatives
- Mevalonic Acid -- metabolism
- Mice
- Neoplasm Proteins
- Osteoblasts -- cytology
- Osteogenesis -- drug effects
- Phosphates -- pharmacology
- Polyisoprenyl Phosphates -- metabolism
- Pravastatin -- pharmacology
- Protein Prenylation
- Sesquiterpenes
- Signal Transduction
- Transcription Factors -- metabolism
- Transforming Growth Factor beta -- metabolism
- Tumor Cells, Cultured
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Publication Type: Journal Article
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