Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.

Izumo, N

Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. [electronic resource] - Methods and findings in experimental and clinical pharmacology Sep 2001 - 389-94 p. digital

Publication Type: Journal Article

0379-0355

10.1358/mf.2001.23.7.662123 doi


Animals
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins--metabolism
Calcification, Physiologic--drug effects
Calcium--metabolism
Cell Line
Core Binding Factor Alpha 1 Subunit
Core Binding Factors
Fatty Acids, Monounsaturated--pharmacology
Fluvastatin
GTPase-Activating Proteins--antagonists & inhibitors
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Immunohistochemistry
Indoles--pharmacology
Lovastatin--analogs & derivatives
Mevalonic Acid--metabolism
Mice
Neoplasm Proteins
Osteoblasts--cytology
Osteogenesis--drug effects
Phosphates--pharmacology
Polyisoprenyl Phosphates--metabolism
Pravastatin--pharmacology
Protein Prenylation
Sesquiterpenes
Signal Transduction
Transcription Factors--metabolism
Transforming Growth Factor beta--metabolism
Tumor Cells, Cultured