Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. [electronic resource]
Producer: 20020116Description: 1161-8 p. digitalISSN:- 0022-3042
- Adenoviridae -- genetics
- Alzheimer Disease -- genetics
- Amino Acid Substitution
- Amyloid beta-Peptides -- biosynthesis
- Animals
- Apoptosis -- drug effects
- Caspase 3
- Caspase Inhibitors
- Caspases -- physiology
- Cells, Cultured
- Cerebral Cortex -- cytology
- Cysteine Proteinase Inhibitors -- pharmacology
- Enzyme Inhibitors -- pharmacology
- Genes, bcl-2
- Genetic Vectors -- genetics
- Humans
- Membrane Proteins -- biosynthesis
- Mutation, Missense
- Nerve Tissue Proteins -- biosynthesis
- Neurons -- cytology
- Presenilin-2
- Protein Isoforms -- biosynthesis
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Rats
- Recombinant Fusion Proteins -- biosynthesis
- Staurosporine -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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