Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons.

Araki, W

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. [electronic resource] - Journal of neurochemistry Dec 2001 - 1161-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3042

10.1046/j.1471-4159.2001.00638.x doi


Adenoviridae--genetics
Alzheimer Disease--genetics
Amino Acid Substitution
Amyloid beta-Peptides--biosynthesis
Animals
Apoptosis--drug effects
Caspase 3
Caspase Inhibitors
Caspases--physiology
Cells, Cultured
Cerebral Cortex--cytology
Cysteine Proteinase Inhibitors--pharmacology
Enzyme Inhibitors--pharmacology
Genes, bcl-2
Genetic Vectors--genetics
Humans
Membrane Proteins--biosynthesis
Mutation, Missense
Nerve Tissue Proteins--biosynthesis
Neurons--cytology
Presenilin-2
Protein Isoforms--biosynthesis
Proto-Oncogene Proteins c-bcl-2--biosynthesis
Rats
Recombinant Fusion Proteins--biosynthesis
Staurosporine--pharmacology