Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo. [electronic resource]
Producer: 20020114Description: 1523-31 p. digitalISSN:- 0007-1188
- Animals
- Anti-Arrhythmia Agents -- pharmacology
- Dose-Response Relationship, Drug
- In Vitro Techniques
- Membrane Potentials -- drug effects
- Mice
- Mice, Mutant Strains
- Muscle Contraction -- drug effects
- Muscle, Skeletal -- drug effects
- Mutation
- Myotonia -- drug therapy
- Rana esculenta
- Sodium Channel Blockers
- Sodium Channels -- physiology
- Stereoisomerism
- Structure-Activity Relationship
- Tocainide -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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