Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo.
Talon, S
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo. [electronic resource] - British journal of pharmacology Dec 2001 - 1523-31 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0007-1188
10.1038/sj.bjp.0704366 doi
Animals
Anti-Arrhythmia Agents--pharmacology
Dose-Response Relationship, Drug
In Vitro Techniques
Membrane Potentials--drug effects
Mice
Mice, Mutant Strains
Muscle Contraction--drug effects
Muscle, Skeletal--drug effects
Mutation
Myotonia--drug therapy
Rana esculenta
Sodium Channel Blockers
Sodium Channels--physiology
Stereoisomerism
Structure-Activity Relationship
Tocainide--chemistry
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo. [electronic resource] - British journal of pharmacology Dec 2001 - 1523-31 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0007-1188
10.1038/sj.bjp.0704366 doi
Animals
Anti-Arrhythmia Agents--pharmacology
Dose-Response Relationship, Drug
In Vitro Techniques
Membrane Potentials--drug effects
Mice
Mice, Mutant Strains
Muscle Contraction--drug effects
Muscle, Skeletal--drug effects
Mutation
Myotonia--drug therapy
Rana esculenta
Sodium Channel Blockers
Sodium Channels--physiology
Stereoisomerism
Structure-Activity Relationship
Tocainide--chemistry