The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. [electronic resource]
Producer: 20011011Description: 9378-92 p. digitalISSN:- 0022-538X
- Animals
- CD4 Antigens -- genetics
- Genes, nef
- HIV Infections -- genetics
- HIV-1 -- genetics
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Protein-Tyrosine Kinases -- genetics
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-hck
- Virulence -- genetics
- Virus Replication -- genetics
- src Homology Domains
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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