The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.
Hanna, Z
The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. [electronic resource] - Journal of virology Oct 2001 - 9378-92 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-538X
10.1128/JVI.75.19.9378-9392.2001 doi
Animals
CD4 Antigens--genetics
Genes, nef
HIV Infections--genetics
HIV-1--genetics
Humans
Mice
Mice, Transgenic
Mutation
Protein-Tyrosine Kinases--genetics
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-hck
Virulence--genetics
Virus Replication--genetics
src Homology Domains
The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. [electronic resource] - Journal of virology Oct 2001 - 9378-92 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-538X
10.1128/JVI.75.19.9378-9392.2001 doi
Animals
CD4 Antigens--genetics
Genes, nef
HIV Infections--genetics
HIV-1--genetics
Humans
Mice
Mice, Transgenic
Mutation
Protein-Tyrosine Kinases--genetics
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-hck
Virulence--genetics
Virus Replication--genetics
src Homology Domains